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The virus infects basal epithelial cells of stratified squamous epithelium. HPV E6 and E7 oncoproteins are the critical molecules in the wart virus pap smear of malignant tumour formation. Interacting with various cellular proteins, E6 and E7 influence fundamental cellular functions like cell cycle regulation, telomere maintenance, susceptibility to apoptosis, intercellular adhesion and regulation of immune responses. High-risk E6 and E7 bind to p53 and pRb and inactivate their functions with dysregulation of the cell cycle.

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Global, HPV este cea mai frecvent transmisă infecţie sexuală, deşi există variaţii regionale semnificative n prevalenţa HPV n regiunile cu aglomeraţie populaţională şi descendenţă comună, ceea ce se poate datora diferenţelor n ceea ce priveşte normele culturale şi sexuale [7]. Studiul realizat de Salih, et al.

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Prevenirea cancerului de col uterin HPV și cancerul de col uterin Cancerul de col uterin se dezvoltă atunci când celulele cervicale devin anormale, apoi se schimbă și devin canceroase. Un virus comun, papilomavirusul uman HPVeste în mare măsură responsabil pentru modificările celulelor normale. Poate wart virus pap smear mulţi ani pentru dezvoltarea cancerului de col uterin. De aceea, detectarea timpurie este extrem de importantă.

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