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The virus infects basal epithelial cells of stratified squamous epithelium. HPV E6 and E7 oncoproteins are the critical molecules in the process of malignant tumour formation. Interacting with various cellular proteins, E6 and E7 influence fundamental cellular functions like cell cycle regulation, telomere maintenance, susceptibility to apoptosis, intercellular adhesion and regulation of immune responses.

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The aim of this study is to present the evolution of cervical cancer in Bucharest, based on incidence, prevalence and mortality routine statistics, in the context of the health programs unfolded by the authorities or by other parties as corporate social responsibility CRS factors. Materials and method. This is a correlation between a study and review of the latest literature using data bases on cervical cancer and the prevalence of its risk factors. In Bucharest, it was initiated an awareness program for female population, and inwith the Government support, there was initiated a vaccination program against HPV, but the vaccination rate was under expectations.

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