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Human papillomaviruses and their possible role in squamous cell carcinomas

The detection of human papillomaviruses in histological preparations by using dot-blot hybridization. Rev Roum Virol.

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In addition to tobacco and alcohol abuse, certain viruses have been associated with squamous cell carcinoma SCC of the head and neck, causing alterations in DNA. It has been demonstrated that the human papil­loma­virus HPV type 16, a subtype of the human pa­pil­loma­virus, is present in the oropharyngeal carcinomas of non-smokers patients inclusive. HPV-infected cells express some viral proteins encoded by genes called E6 and E7, and can inactivate p53 protein and the retinoblastoma-type laryngeal papilloma cells RBP involved in the regulation of proliferation and cell death. Materials and method.

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